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This is due to the finite speed of signal propagation and the vast distances in space. The crew finds itself in information isolation and is forced to rely solely on autonomous systems and their own decisions without the possibility of rapid data exchange or social contact with the home planet.
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An additional difficulty is created by the effect of time dilation: for people on board, interstellar travel can take only tens of years, while for observers on Earth it stretches out over thousands or millions of years.